1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

Base Information

Chemical Name:1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione
CAS No.:1263093-15-7
Molecular Formula:C₁₇H₁₉F₃N₂O₂
Molecular Weight:340.345
Hs Code.:

Synonyms:1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

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Chemical Property of 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

Chemical Property:

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Technology Process of 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

There total 9 articles about 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263093-14-6
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1263093-15-7
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

Guidance literature:: at 20 ℃; for 16h;

Reference yield:

: 1263093-11-3
N-(3-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-2-methyl-6-(trifluoromethyl)phenyl)formamide

: 1263093-15-7
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 4 h / Reflux

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

2.2: 20 °C

3.1: trifluoroacetic acid / Reflux

4.1: 16 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; water;

Reference yield:

: 1263093-09-9
2-[3-fluoro-4-(trifluoromethyl)phenyl]-4,4-dimethyl-5H-oxazole

: 1263093-15-7
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-2-[(dimethylamino)methylene]propane-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

1.2: -70 - 20 °C

2.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

2.2: 0.75 h / 140 °C

3.1: hydrogenchloride / water / 4 h / Reflux

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / Reflux

6.1: 16 h / 20 °C

With hydrogenchloride; n-butyllithium; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; n-heptane; ISOPROPYLAMIDE; water;