1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

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Chemical Name:1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea
CAS No.:1402743-73-0
Molecular Formula:C₃₄H₃₄F₉N₅O₂S
Molecular Weight:747.728
Hs Code.:

1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

Synonyms:1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

There total 5 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 463-71-8
thiophosgene

: 1402743-82-1
1-(2-(((1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

: 894493-95-9
(1S,2S)-N,N-dimethylcyclohexane-1,2-diamine

: 1402743-73-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

Guidance literature:: thiophosgene; 1-(2-(((1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea; With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water; at 0 ℃; for 2h;

(1S,2S)-N,N-dimethylcyclohexane-1,2-diamine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1002/anie.201203852

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1-(2-(((1R,2R)-1-(3-((1S,2S)-2-aminocyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)-3-(3,5-bis-(trifluoromethyl)phenyl)urea

: 1402743-73-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

Guidance literature:: formaldehyd; 1-(2-(((1R,2R)-1-(3-((1S,2S)-2-aminocyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)-3-(3,5-bis-(trifluoromethyl)phenyl)urea; In water; 1,2-dichloro-ethane; at 20 ℃; for 0.25h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In water; 1,2-dichloro-ethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/acs.joc.9b01980

Reference yield:

: 766556-66-5
tert-butyl [(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-carbamate

: 1402743-73-0
1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(((1R,2R)-1-(3-((1S,2S)-2-(dimethylamino)cyclohexyl)thioureido)-2,3-dihydro-1H-inden-2-yl)oxy)-5-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C

2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate

3.1: tetrahydrofuran / 0.75 h / 0 - 20 °C

3.2: 16 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; dichloromethane; water / 2 h / 0 °C

4.2: 12 h / 0 - 20 °C

With 5%-palladium/activated carbon; hydrogen; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1002/anie.201203852