N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide

Base Information

• Chemical Name: N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide
• CAS No.: 1385068-93-8
• Molecular Formula: C₂₄H₃₅N₃O₇S
• Molecular Weight: 509.624

Synonyms:N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide

Chemical Property of N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide

There total 3 articles about N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine (1385068-39-2) + methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate (1385068-88-1) → N1-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N3-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide (1385068-93-8)

Guidance literature:

methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate; With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1.16667h;

(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2012.05.039

Reference yield:

3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid (695215-94-2) → N1-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N3-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide (1385068-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 19 h / 0 - 20 °C

2.1: lithium hydroxide / 1,4-dioxane; water / 1.17 h / 20 °C

2.2: 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.05.039

Reference yield:

(S)-4-((S)-2-(allyloxy)-1-azidoethyl)-2,2-dimethyl-1,3-dioxolane (1385068-34-7) → N1-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N3-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide (1385068-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1.3-propanedithiol; triethylamine / methanol / 22 h / 20 °C

2.1: lithium hydroxide / 1,4-dioxane; water / 1.17 h / 20 °C

2.2: 16 h / 20 °C

With 1.3-propanedithiol; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.bmc.2012.05.039

upstream raw materials:

(S)-4-((S)-2-(allyloxy)-1-azidoethyl)-2,2-dimethyl-1,3-dioxolane

(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine

methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid

Downstream raw materials:

N-((S)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-trien-16-yl)-N-methyl-methanesulfonamide

N-[(S)-4-((R)-2-benzylamino-1-hydroxy-ethyl)-2,13-dioxo-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-trien-16-yl]-N-methyl-methanesulfonamide

N-((E)-(S)-4-[(R)-2-(3-tert-butyl-benzylamino)-1-hydroxy-ethyl]-2,13-dioxo-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁷⁾,8,14⁽¹⁸⁾,15-tetraen-16-yl)-N-methyl-methanesulfonamide

N-[(E)-(S)-4-((R)-2-benzylamino-1-hydroxy-ethyl)-2,13-dioxo-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁷⁾,8,14⁽¹⁸⁾,15-tetraen-16-yl]-N-methyl-methanesulfonamide

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