methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

Base Information

Chemical Name:methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate
CAS No.:1385068-88-1
Molecular Formula:C₁₅H₂₀N₂O₅S
Molecular Weight:340.4
Hs Code.:

Synonyms:methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

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Chemical Property of methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

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Technology Process of methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

There total 1 articles about methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 17875-18-2
but-3-en-1-amine hydrochloride

: 695215-94-2
3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid

: 1385068-88-1
methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 19h;
DOI:10.1016/j.bmc.2012.05.039

Reference yield: 90.0%

: 1385068-39-2
(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine

: 1385068-88-1
methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

: 1385068-93-8
N₁-((S)-2-allyloxy-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl)-N₃-but-3-enyl-5-(methanesulfonyl-methyl-amino)-isophthalamide

Guidance literature:: methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate; With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1.16667h;

(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2012.05.039

Reference yield:

: 1385068-88-1
methyl 3-(but-3-en-1-ylcarbamoyl)-5-(n-methylmethyl-sulfonamido)benzoate

: C₂₆H₃₅N₃O₉S₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide / 1,4-dioxane; water / 1.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: acetic acid / water / 1.75 h / 60 °C

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / Inert atmosphere; Reflux

4.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

5.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 23 h / 20 °C

With Hoveyda-Grubbs catalyst second generation; palladium 10% on activated carbon; hydrogen; di(n-butyl)tin oxide; acetic acid; triethylamine; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.05.039