1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Base Information

• Chemical Name: 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
• CAS No.: 2616-24-2
• Molecular Formula: C₂₀H₂₃NO₃
• Molecular Weight: 325.408
• Mol file: 2616-24-2.mol

Synonyms:1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Chemical Property of 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

There total 4 articles about 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide (340829-04-1) → 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (2616-24-2)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.3390/molecules16087019

Reference yield: 90.0%

1,1-diethoxy-2-phenylethane (6314-97-2) + N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2) → 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (2616-24-2)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 6h; Heating;

DOI:10.1080/00397919608086750

Reference yield:

N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2) → 1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (2616-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1: polyphosphoric acid / dichloromethane / 20 h / 60 °C

2: methanol; sodium tetrahydroborate / 0.5 h / 20 °C

3: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; toluene-4-sulfonic acid; In dichloromethane; 1: Friedel Crafts acylation;

DOI:10.3390/molecules16087019

upstream raw materials:

1,1-diethoxy-2-phenylethane

N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide