N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide

Base Information

• Chemical Name: N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide
• CAS No.: 340829-04-1
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.423
• Mol file: 340829-04-1.mol

Synonyms:N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide

Chemical Property of N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide

There total 8 articles about N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(4,5-dimethoxy-2-(2-phenylacetyl)phenethyl)acetamide (121089-87-0) → N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide (340829-04-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 3.5h;

DOI:10.1016/S0040-4020(01)00041-2

Reference yield:

N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (6275-29-2) → N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide (340829-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / dichloromethane / 20 h / 60 °C

2: methanol; sodium tetrahydroborate / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; In dichloromethane; 1: Friedel Crafts acylation;

DOI:10.3390/molecules16087019

Reference yield:

N-(3,4-dimethoxyphenethyl)-phenyl acetamide (4876-02-2) → N-(2-(1-hydroxy-2-phenylethyl)-4,5-dimethoxyphenethyl)acetamide (340829-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / aq. HCl / methanol / 5 h / Heating

2: 100 percent / NaBH₄ / tetrahydrofuran / 3.5 h

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; methanol; 1: Bichler-Napieralski cyclization;

DOI:10.1016/S0040-4020(01)00041-2

upstream raw materials:

N-(4,5-dimethoxy-2-(2-phenylacetyl)phenethyl)acetamide

N-(3,4-dimethoxyphenethyl)-phenyl acetamide

1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

1-(1-benzyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

7,8-Dimethoxy-1-methyl-5-((E)-styryl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester

7,8-Dimethoxy-1-methyl-5-((E)-styryl)-1,2,3,4-tetrahydro-isoquinoline

7,8-Dimethoxy-1-methyl-5-((E)-styryl)-3,4-dihydro-isoquinoline