N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

Base Information

Chemical Name:N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide
CAS No.:1616380-50-7
Molecular Formula:C₂₂H₂₄FN₅O₄
Molecular Weight:441.462
Hs Code.:

Synonyms:N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

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Chemical Property of N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

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Technology Process of N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

There total 10 articles about N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-83-6
ethyl 3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-3-oxopropanoate

: 1616380-50-7
N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

Guidance literature:: With sodium tetrahydroborate; lithium bromide; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

: 1616380-50-7
N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / ethanol / 24 h / Reflux

2: trifluoroacetic acid / dichloromethane / 0.75 h / 0 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

4: sodium tetrahydroborate; lithium bromide / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium bromide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1616380-50-7
N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2: acetic acid / tert-Amyl alcohol / 4 h / Reflux

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

4: lithium bromide; sodium tetrahydroborate / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

With sodium tetrahydroborate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; tert-Amyl alcohol; N,N-dimethyl-formamide;