tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate
• CAS No.: 1202759-90-7
• Molecular Formula: C₂₄H₂₈FN₅O₄
• Molecular Weight: 469.516

Synonyms:tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate

Chemical Property of tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate

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Technology Process of tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate

There total 9 articles about tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate (1202759-89-4) + 4-(2-methoxyethoxy)aniline (33311-29-4) → tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate (1202759-90-7)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; for 24h; Solvent; Reagent/catalyst; Reflux;

Reference yield:

tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate (1202759-89-4) + 4-(2-methoxy-ethoxy)-aniline; hydrochloride (10141-52-3) → tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate (1202759-90-7)

Guidance literature:

acetic acid; In tert-Amyl alcohol; for 4h; Reflux;

Reference yield:

tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate (1202759-89-4) + 4-(2-methoxyethoxy)aniline (33311-29-4) → N4-(3-aminophenyl)-5-fluoro-N2-(4-(2-methoxyethoxy)phenyl)pyrimidine-2,4-diamine (1202759-91-8) + tert-butyl (3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino) pyrimidin-4-yl)amino)phenyl)carbamate (1202759-90-7)

Guidance literature:

With acetic acid; In tert-Amyl alcohol; for 4h; Reflux;

upstream raw materials:

tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

4-(2-methoxy-ethoxy)-aniline; hydrochloride

(3-aminophenyl)carbamic acid tert-butyl ester

4-(2-methoxyethoxy)aniline

Downstream raw materials:

ethyl 3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-3-oxopropanoate

N-(3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-3-hydroxypropanamide

N-(3-{5-fluoro-2-[4-(2-methoxy-ethoxy)-phenylamino]-pyrimidin-4-ylamino}-phenyl)-acrylamide

3-((3-((5-fluoro-2-((4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate

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