C₂₄H₂₉FN₂O₄Si

Base Information

• Chemical Name: C₂₄H₂₉FN₂O₄Si
• CAS No.: 1374110-21-0
• Molecular Formula: C₂₄H₂₉FN₂O₄Si
• Molecular Weight: 456.589
• Mol file: 1374110-21-0.mol

Synonyms:C₂₄H₂₉FN₂O₄Si

Chemical Property of C₂₄H₂₉FN₂O₄Si

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₂₄H₂₉FN₂O₄Si

There total 4 articles about C₂₄H₂₉FN₂O₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-tert-butyldimethylsiloxy-3-fluoro-1-propanol (1374108-27-6) + C15H10N2O3 (1374110-20-9) → C24H29FN2O4Si (1374110-21-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h; Cooling with ice;

Reference yield:

2-Chloroquinoline (612-62-4) → C24H29FN2O4Si (1374110-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 16 h / 90 °C / Inert atmosphere

2: 2-(methylsulfonyl)ethyl alcohol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-(methylsulfonyl)ethyl alcohol; di-isopropyl azodicarboxylate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-(3-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (939968-60-2) → C24H29FN2O4Si (1374110-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 16 h / 90 °C / Inert atmosphere

2: 2-(methylsulfonyl)ethyl alcohol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-(methylsulfonyl)ethyl alcohol; di-isopropyl azodicarboxylate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-tert-butyldimethylsiloxy-3-fluoro-1-propanol

C₁₅H₁₀N₂O₃

2-Chloroquinoline

2-(3-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

C₂₄H₃₁FN₂O₂Si