S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

Base Information

Chemical Name:S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate
CAS No.:1376702-44-1
Molecular Formula:C₁₇H₂₄O₃S
Molecular Weight:308.442
Hs Code.:

Synonyms:S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

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Chemical Property of S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

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Technology Process of S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

There total 6 articles about S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376702-21-4
(E)-S-(2,6-dimethylphenyl) 4-hydroxybut-2-enethioate

: 630-19-3
pivalaldehyde

: 1376702-46-3
S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

: 1376702-44-1
S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

Guidance literature:: With N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]thiourea; In cyclopentyl methyl ether; at 25 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c2cc31602a

Reference yield:

: 2,6-dimethylbenzenethiol ester

: 630-19-3
pivalaldehyde

: 1376702-46-3
S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

: 1376702-44-1
S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

Guidance literature:: With N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]thiourea; at 25 ℃; for 48h; Overall yield = 85 %; enantioselective reaction;
DOI:10.1055/s-0032-1316920

Reference yield:

: 118-72-9
2,6-dimethylbenzene-1-thiol

: 1376702-46-3
S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

: 1376702-44-1
S-(2,6-dimethylphenyl) 2-(2-(tert-butyl)-1,3-dioxolan-4-yl)ethanethioate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0.58 h / 0 - 20 °C

2: dichloromethane; benzene / 18 h / 20 °C

3: sodium hydroxide / dichloromethane; water / 0.5 h

4: tetrahydrofuran / 20 - 80 °C

5: N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]thiourea / cyclopentyl methyl ether / 48 h / 25 °C

With N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]thiourea; pyridine; sodium hydroxide; In tetrahydrofuran; dichloromethane; cyclopentyl methyl ether; water; benzene; 5: oxy-Michael addition;
DOI:10.1039/c2cc31602a