3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

Base Information

Chemical Name:3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine
CAS No.:171614-05-4
Molecular Formula:C₃₆H₄₃N₅O₆Si
Molecular Weight:669.853
Hs Code.:

Synonyms:3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

Chemical Property:

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Technology Process of 3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

There total 5 articles about 3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 171614-04-3
3'-O-(tert-butyldimethylsilyl)-5'-O-(dimethoxytrityl)-2'-(phenoxythiocarbonyl)-2-azainosine

: 171614-05-4
3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; for 0.25h; Ambient temperature;
DOI:10.1021/jo00125a009

Reference yield:

: 36519-16-1
7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

: 171614-05-4
3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / pyridine

2: 55 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

3: 81 percent / DMAP / acetonitrile / 3 h / Ambient temperature

4: 55 percent / Bu₃SnH, AIBN / tetrahydrofuran / 0.25 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00125a009

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 171614-05-4
3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / pyridine

2: 55 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

3: 81 percent / DMAP / acetonitrile / 3 h / Ambient temperature

4: 55 percent / Bu₃SnH, AIBN / tetrahydrofuran / 0.25 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00125a009