7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one

Base Information

• Chemical Name: 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one
• CAS No.: 1053692-67-3
• Molecular Formula: C₄₃H₄₈N₆O₈Si
• Molecular Weight: 804.975

Synonyms:

Chemical Property of 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one

There total 6 articles about 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one (36519-16-1) → 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one (1053692-67-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 62 percent / pyridine

2: 55 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

3: 81 percent / DMAP / acetonitrile / 3 h / Ambient temperature

4: 55 percent / Bu₃SnH, AIBN / tetrahydrofuran / 0.25 h / Ambient temperature

5: Ph₃P, DEAD / dioxane / 2 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; pyridine; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo00125a009

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one (1053692-67-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 62 percent / pyridine

2: 55 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

3: 81 percent / DMAP / acetonitrile / 3 h / Ambient temperature

4: 55 percent / Bu₃SnH, AIBN / tetrahydrofuran / 0.25 h / Ambient temperature

5: Ph₃P, DEAD / dioxane / 2 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; pyridine; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo00125a009

Reference yield:

5'-O-(dimethoxytrityl)-2-azainosine (171614-02-1) → 7-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-nitro-benzyl)-3,7-dihydro-imidazo[4,5-d][1,2,3]triazin-4-one (1053692-67-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 81 percent / DMAP / acetonitrile / 3 h / Ambient temperature

3: 55 percent / Bu₃SnH, AIBN / tetrahydrofuran / 0.25 h / Ambient temperature

4: Ph₃P, DEAD / dioxane / 2 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo00125a009

upstream raw materials:

2-Nitrobenzyl alcohol

3'-O-(tert-butyldimethylsilyl)-5'-O(dimethoxytrityl)-2-aza-2'-deoxyinosine

7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

4,4'-dimethoxytrityl chloride

Downstream raw materials:

5'-O-(dimethoxytrityl)-N¹-(2-nitrobenzyl)-2-aza-2'-deoxyinosine

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