1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

Base Information

Chemical Name:1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea
CAS No.:874476-58-1
Molecular Formula:C₂₉H₃₀N₄O₂SSi
Molecular Weight:526.734
Hs Code.:

1-benzoyl-3-[5-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

Synonyms:1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

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Chemical Property of 1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

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Technology Process of 1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

There total 7 articles about 1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 874476-57-0
5-(tert-butyldiphenylsilanyloxymethyl)pyrazin-2-ylamine

: 532-55-8
Benzoyl isothiocyanate

: 874476-58-1
1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.04.048

Reference yield:

: 874476-55-8
(5-hydroxymethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

: 874476-58-1
1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: 92 percent / TFA / CHCl₃ / 5 h / 20 °C

3: 96 percent / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; trifluoroacetic acid; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.048

Reference yield:

: 874476-54-7
acetic acid 5-tert-butoxycarbonylamino-pyrazin-2-yl-methyl ester

: 874476-58-1
1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 12 h / 20 °C

2: 99 percent / imidazole / dimethylformamide / 12 h / 20 °C

3: 92 percent / TFA / CHCl₃ / 5 h / 20 °C

4: 96 percent / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; sodium hydroxide; trifluoroacetic acid; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.048