874476-57-0

Basic information

• Product Name: 5-(tert-butyldiphenylsilanyloxymethyl)pyrazin-2-ylamine
• Synonyms: 5-(tert-butyldiphenylsilanyloxymethyl)pyrazin-2-ylamine
• CAS NO: 874476-57-0
• Molecular Weight: 363.535
• Mol File: 874476-57-0.mol

Chemical Properties

• CAS DataBase Reference: 5-(tert-butyldiphenylsilanyloxymethyl)pyrazin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(tert-butyldiphenylsilanyloxymethyl)pyrazin-2-ylamine(874476-57-0)
• EPA Substance Registry System: 5-(tert-butyldiphenylsilanyloxymethyl)pyrazin-2-ylamine(874476-57-0)

Safety Data

• Hazardous Substances Data: 874476-57-0(Hazardous Substances Data)

Upstream product

• 5521-55-1 2-methylpyrazin-5-carboxylic acid 
• 72788-89-7 2-hydroxymethyl-5-amino-pyrazine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 369638-69-7 tert-butyl (5-(bromomethyl)pyrazin-2-yl)carbamate 
• 369638-68-6 tert-butyl (5-methylpyrazin-2-yl)carbamate 
• 874476-54-7 acetic acid 5-tert-butoxycarbonylamino-pyrazin-2-yl-methyl ester 
• 874476-55-8 (5-hydroxymethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester 
• 874476-56-9 [5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-carbamic acid tert-butyl ester 

Downstream Products

• 1034309-44-8 6-(tert-butyldiphenylsilanyloxymethyl)-2-methylimidazo[1,2-a]pyrazine 
• 874476-59-2 [5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea 
• 874476-58-1 1-benzoyl-3-[5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrazin-2-yl]-thiourea 

Relevant articles and documents

INDOLYLMALEIMIDE DERIVATIVES

A compound of formula (I) wherein R denotes another heterocylic residue and wherein Ra, Rb, Rc, Rd and Re, are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

SELECTIVE INHIBITORS AGAINST Cdk4 AND Cdk6 HAVING AMINOTHIAZOLE SKELETON

The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH 2 ; Y 1 , Y 2 , Y 3 , Y 4 and Y 5 , which may be identical or different, are each CH or N; however, at least one of Y 1 , Y 2 , Y 3 , Y 4 and Y 5 is N; Z 1 and Z 2 , which may be identical or different, are each CH or N; n is an integer from 1 to 3; R 1 is a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R 2 and R 3 , which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aromatic heterocyclic ring, or the like; and R 4 is a hydrogen atom, a lower alkyl group, a C 3 -C 6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9

5-Pyrimidinyl-2-aminothiazole 1 was identified as an inhibitor of cyclin-dependent kinases (CDKs) by a screening of the Merck sample repository. The introduction of a methyl group at the C-5 or C-6 position on the pyrimidine ring, directed toward the gate