5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine
CAS No.:1363293-82-6
Molecular Formula:C₂₁H₁₄Cl₂FN₃
Molecular Weight:398.267
Hs Code.:

Synonyms:5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

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Chemical Property of 5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

Chemical Property:

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Technology Process of 5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

There total 3 articles about 5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363293-80-4
2-cyclopropyl3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidin-5(4H)-one

: 1363293-82-6
5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

Guidance literature:: With pyridine; trichlorophosphate; for 3h; Heating;

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 1363293-82-6
5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

2: acetic acid; hydrazine hydrate / toluene / 16 h / Heating

3: pyridine / 95 °C

4: trichlorophosphate; pyridine / 3 h / Heating

With pyridine; sodium hydride; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; toluene; mineral oil;

Reference yield:

: 110347-82-5
2-(4-chlorophenyl)-2-cyclopropylcarbonylacetonitrile

: 1363293-82-6
5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrazine hydrate / toluene / 16 h / Heating

2: pyridine / 95 °C

3: trichlorophosphate; pyridine / 3 h / Heating

With pyridine; hydrazine hydrate; acetic acid; trichlorophosphate; In toluene;