(S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

Base Information

Chemical Name:(S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol
CAS No.:1363285-88-4
Molecular Formula:C₂₆H₂₄ClFN₄O
Molecular Weight:462.954
Hs Code.:

Synonyms:(S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

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Chemical Property of (S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

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Technology Process of (S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

There total 5 articles about (S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363293-82-6
5-chloro-2-cyclopropyl-3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidine

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 1363285-88-4
(S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃;

Reference yield:

: 1363293-80-4
2-cyclopropyl3-(4-chlorophenyl)-7-(4-fluorophenyl)-pyrazolo[1,5-a]pyrimidin-5(4H)-one

: 1363285-88-4
(S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; pyridine / 3 h / Heating

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

With pyridine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetonitrile;

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 1363285-88-4
(S)-(1-(3-(4-chlorophenyl)-7-(4-fluorophenyl)-2-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

2: acetic acid; hydrazine hydrate / toluene / 16 h / Heating

3: pyridine / 95 °C

4: trichlorophosphate; pyridine / 3 h / Heating

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

With pyridine; sodium hydride; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; toluene; acetonitrile; mineral oil;