4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Base Information

Chemical Name:4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide
CAS No.:186094-17-7
Molecular Formula:C₂₇H₃₆IN₃O
Molecular Weight:545.507
Hs Code.:

Synonyms:4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Suppliers and Price of 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

There total 11 articles about 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.2%

: 155836-78-5
(-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine

: 186094-13-3
4-[Chloro-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

: 186094-17-7
4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

: 4-[(S)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; for 84h; Heating;
DOI:10.1021/jm960319n

Reference yield:

: 1711-10-0
3-iodobenzoyl chloride

: 186094-17-7
4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: AlCl₃ / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 53.5 percent / KMnO₄ / 2-methyl-propan-2-ol; H₂O / 39 h / Heating

3: SOCl₂ / benzene / 3 h / Heating

4: CHCl₃ / 4 h / Ambient temperature

5: NaBH₄ / methanol / 0.5 h / Ambient temperature

6: 78 percent / 37percent aq. HCl / CHCl₃ / Ambient temperature

7: 40.2 percent / K₂COP₃, tetrabutylammonium iodide / acetonitrile / 84 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; aluminium trichloride; thionyl chloride; tetra-(n-butyl)ammonium iodide; In methanol; dichloromethane; chloroform; water; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jm960319n

Reference yield:

: 107622-31-1
3-iodo-4'-methylbenzophenone

: 186094-17-7
4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-iodo-phenyl)-methyl]-N,N-diethyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 53.5 percent / KMnO₄ / 2-methyl-propan-2-ol; H₂O / 39 h / Heating

2: SOCl₂ / benzene / 3 h / Heating

3: CHCl₃ / 4 h / Ambient temperature

4: NaBH₄ / methanol / 0.5 h / Ambient temperature

5: 78 percent / 37percent aq. HCl / CHCl₃ / Ambient temperature

6: 40.2 percent / K₂COP₃, tetrabutylammonium iodide / acetonitrile / 84 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; thionyl chloride; tetra-(n-butyl)ammonium iodide; In methanol; chloroform; water; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jm960319n