N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide

Base Information

• Chemical Name: N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide
• CAS No.: 86439-27-2
• Molecular Formula: C₁₆H₁₈N₂O₆S
• Molecular Weight: 366.395
• Mol file: 86439-27-2.mol

Synonyms:N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide

Chemical Property of N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide

There total 1 articles about N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide (3360-81-4) + 2-chloro-ethanol (107-07-3) → N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide (86439-27-2)

Guidance literature:

With sodium; Yield given. Multistep reaction; 1.) methanol, reflux, 0.5 h; 2.) DMF, 120 deg C, 10 h;

DOI:10.1016/S0040-4020(01)88550-1

Reference yield: 92.0%

N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide (86439-27-2) → 2'-amino-N-(2-hydroxyethyl)-4'-methoxytosylanilide (86439-28-3)

Guidance literature:

palladium on activated charcoal; In isopropyl alcohol; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)88550-1

Reference yield:

N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide (86439-27-2) → 9-methoxy-2-methyl-6-tosyl-5,6-dihydro-4H-3,1,6-benzoxadiazocine (86439-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 8percent Pd/C / propan-2-ol / 760 Torr / Ambient temperature

2: 49 percent / 6 h / Heating

3: 55 percent / NaOMe / dioxane / 8 h / Heating

palladium on activated charcoal; sodium methylate; In 1,4-dioxane; isopropyl alcohol;

DOI:10.1016/S0040-4020(01)88550-1

upstream raw materials:

N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

2-chloro-ethanol

Downstream raw materials:

2'-amino-N-(2-hydroxyethyl)-4'-methoxytosylanilide

9-methoxy-2-methyl-6-tosyl-5,6-dihydro-4H-3,1,6-benzoxadiazocine

ethyl N-<2--4-methoxyphenyl>acetamidate

1-acetyl-2-ethoxy-9-methoxy-2-methyl-6-tosyl-1,4,5,6-tetrahydro-2H-3,1,6-benzoxadiazocine