3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane

Base Information

• Chemical Name: 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane
• CAS No.: 117581-97-2
• Molecular Formula: C₁₇H₂₉FO₂Si
• Molecular Weight: 312.5
• Mol file: 117581-97-2.mol

Synonyms:3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane

Chemical Property of 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane

There total 3 articles about 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-benzyloxy-2-fluoro-2-methylpropanol (117581-96-1) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane (117581-97-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1021/jo00262a023

Reference yield:

benzyl bromide (100-39-0) → 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane (117581-97-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH, 2.) tetra-n-butylammonium iodide (TBAI) / 1.) THF, 0 deg C, 1 h, 2.) RT, overnight

2: 94 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

3: 89 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jo00262a023

Reference yield:

ethyl 3-(benzyloxy)-2-fluoro-2-methylpropionate (117581-95-0) → 3-(tert-butyldimethylsiloxy)-2-fluoro-2-methyl-1-(benzyloxy)propane (117581-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

2: 89 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jo00262a023

upstream raw materials:

3-benzyloxy-2-fluoro-2-methylpropanol

tert-butyldimethylsilyl chloride

benzyl bromide

ethyl 3-(benzyloxy)-2-fluoro-2-methylpropionate