9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

Base Information

Chemical Name:9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one
CAS No.:174157-80-3
Molecular Formula:C₂₄H₃₃N₅O₄
Molecular Weight:455.557
Hs Code.:

Synonyms:9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

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Chemical Property of 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

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Technology Process of 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

There total 6 articles about 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 174157-79-0
2-(p-n-octylanilino)-6-chloro-(2-deoxy-β-D-ribofuranosyl)purine

: 174157-80-3
9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

Guidance literature:: With sodium methylate; 2-hydroxyethanethiol; In methanol; ethanol; for 72h; Heating;
DOI:10.1080/07328319608002414

Reference yield:

: 16245-79-7
4-octylaniline

: 174157-80-3
9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / 2-methoxy-ethanol / reflux, 5 h, rt, overnight

2: 1.) SOCl₂, 2.) conc. NH₄OH / 1.) DMF, 70 deg C, 5 h, rt, overnight, 2.) 24 h, rt

3: 78 percent / NaH / acetonitrile; paraffin / 1.33 h / Ambient temperature

4: 83.3 percent / Na, MeOH / 4 h / Ambient temperature

5: 88 percent / OHCH₂CH₂SH, NaOMe / ethanol; methanol / 72 h / Heating

With methanol; ammonium hydroxide; thionyl chloride; sodium methylate; sodium; sodium hydride; 2-hydroxyethanethiol; In methanol; ethanol; 2-methoxy-ethanol; acetonitrile; paraffin;
DOI:10.1080/07328319608002414

Reference yield:

: 87781-93-9
2-bromohypoxanthine

: 174157-80-3
9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(4-octyl-phenylamino)-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / 2-methoxy-ethanol / reflux, 5 h, rt, overnight

2: 1.) SOCl₂, 2.) conc. NH₄OH / 1.) DMF, 70 deg C, 5 h, rt, overnight, 2.) 24 h, rt

3: 78 percent / NaH / acetonitrile; paraffin / 1.33 h / Ambient temperature

4: 83.3 percent / Na, MeOH / 4 h / Ambient temperature

5: 88 percent / OHCH₂CH₂SH, NaOMe / ethanol; methanol / 72 h / Heating

With methanol; ammonium hydroxide; thionyl chloride; sodium methylate; sodium; sodium hydride; 2-hydroxyethanethiol; In methanol; ethanol; 2-methoxy-ethanol; acetonitrile; paraffin;
DOI:10.1080/07328319608002414