N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide

Base Information

• Chemical Name: N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide
• CAS No.: 126088-65-1
• Molecular Formula: C₂₄H₁₉NO₃
• Molecular Weight: 369.42
• Mol file: 126088-65-1.mol

Synonyms:N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide

Chemical Property of N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide

There total 4 articles about N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-anilino-1-(2-hydroxyphenyl)-1-propanone (137709-28-5) + phenylpropyolic acid (637-44-5) → N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide (126088-65-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/S0040-4039(00)99304-3

Reference yield:

1-(2-hydroxyphenyl)-2-propen-1-one (1467-39-6) → N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide (126088-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: 82 percent / dicyclohexylcarbodiimide / CH₂Cl₂

With dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1016/S0040-4039(00)99304-3

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → N-<3-(2-hydroxyphenyl)-3-oxo-propyl>-N-phenyl-phenylpropiolamide (126088-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: LDA

2: c-H₂SO₄ / benzene

3: ethanol

4: 82 percent / dicyclohexylcarbodiimide / CH₂Cl₂

With sulfuric acid; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In ethanol; dichloromethane; benzene;

DOI:10.1016/S0040-4039(00)99304-3

upstream raw materials:

3-anilino-1-(2-hydroxyphenyl)-1-propanone

phenylpropyolic acid

1-(2-hydroxyphenyl)-2-propen-1-one

o-hydroxyacetophenone

Downstream raw materials:

5-acetoxy-2,9-diphenyl-2,3-dihydro-1H-benzisoindol-1-one

4,5-diacetoxy-2,9-diphenyl-2,3-dihydro-1H-benzisoindol-1-one

4-acetoxy-2,9-diphenyl-2,3,5,6,7,8-hexahydro-1H-benzisoindole-1,5-dione