5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

Base Information

Chemical Name:5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid
CAS No.:125558-36-3
Molecular Formula:C₁₆H₁₈BrNO₈
Molecular Weight:432.225
Hs Code.:

Synonyms:5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

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Chemical Property of 5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

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Technology Process of 5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

There total 3 articles about 5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73219-89-3
3-bromo-2,6-dimethoxybenzoic acid

: 125558-36-3
5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂, N,N-dimethylformamide / toluene / 1 h / 60 °C

2: 5.3 g / triethylamine / CH₂Cl₂ / Ambient temperature

3: 1.) lithium diisopropylamide / 1.) THF, hexane, -70 deg C, 1 h, 2.) -60 deg C, 1 h

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; lithium diisopropyl amide; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.43-0476

Reference yield:

: 84225-91-2
5-bromo-2,6-dimethoxybenzoic acid chloride

: 125558-36-3
5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 5.3 g / triethylamine / CH₂Cl₂ / Ambient temperature

2: 1.) lithium diisopropylamide / 1.) THF, hexane, -70 deg C, 1 h, 2.) -60 deg C, 1 h

With triethylamine; lithium diisopropyl amide; In dichloromethane;
DOI:10.3891/acta.chem.scand.43-0476

Reference yield:

: 108-30-5
succinic acid anhydride

: 125558-35-2
methyl 3-bromo-2,6-dimethoxybenzamidoacetate

: 125558-36-3
5-(3-bromo-2,6-dimethoxybenzamido)-5-methoxycarbonyl-4-oxopentanoic acid

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -70 deg C, 1 h, 2.) -60 deg C, 1 h;
DOI:10.3891/acta.chem.scand.43-0476