5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

Base Information

Chemical Name:5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile
CAS No.:1070973-08-8
Molecular Formula:C₂₃H₂₀ClN₃O₃S
Molecular Weight:453.949
Hs Code.:

Synonyms:5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

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Chemical Property of 5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

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Technology Process of 5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

There total 10 articles about 5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1070973-08-8
5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; bromine; sodium nitrite / water / 1 h / 0 - 5 °C

1.2: pH ~ 13

2.1: n-butyllithium / toluene; pentane / 2 h / -78 °C

2.2: 1 h / -78 °C

3.1: trichlorophosphate / toluene / 5 h / Heating / reflux

3.2: Alkaline aqueous solution

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C

With n-butyllithium; hydrogen bromide; bromine; potassium carbonate; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; toluene; pentane;

Reference yield:

: 886364-86-9
5-bromo-4-methyl-pyridine-2-carbonitrile

: 5-chloro-2-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-4-(4,4,5,5-tetramethyl[1,3]dioxolan-2-yl)phenol

: 1070973-08-8
5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 16h;

Reference yield:

: 1701-57-1
2,3,4,5-tetrahydro-1Hbenzo[b]azepine

: 1070973-08-8
5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 16 h

2.1: methanol; dichloromethane / 3 h / 20 °C

2.2: pH 7

3.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 15 h / 90 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C

With potassium acetate; boron tribromide; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water;