5-Bromo-4-methylpyridine-2-carbonitrile

Base Information

• Chemical Name: 5-Bromo-4-methylpyridine-2-carbonitrile
• CAS No.: 886364-86-9
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933399090
• European Community (EC) Number: 691-626-9
• DSSTox Substance ID: DTXSID10694156
• Wikidata: Q72447875
• Mol file: 886364-86-9.mol

Synonyms:886364-86-9;5-Bromo-4-methylpicolinonitrile;5-Bromo-2-cyano-4-methylpyridine;5-Bromo-4-methylpyridine-2-carbonitrile;5-bromo-4-methyl-pyridine-2-carbonitrile;5-BROMO-4-METHYL-2-PYRIDINECARBONITRILE;SCHEMBL153228;DTXSID10694156;JAQLBGDFALXUMV-UHFFFAOYSA-N;AMY19011;MFCD07375090;AKOS006286089;AB41150;CS-W019687;FS-3207;FT-0718070;A853517;J-517100;5-Bromo-4-methylpyridine-2-carbonitrile, AldrichCPR

Chemical Property of 5-Bromo-4-methylpyridine-2-carbonitrile

Chemical Property:

• Boiling Point: 293.289 °C at 760 mmHg
• PKA: -2.02±0.18(Predicted)
• Flash Point: 131.177 °C
• PSA: 36.68000
• Density: 1.613 g/cm³
• LogP: 2.02418
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.96361
• Heavy Atom Count: 10
• Complexity: 160

Purity/Quality:

98%, ^*data from raw suppliers

5-bromo-4-methylpyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1Br)C#N

Technology Process of 5-Bromo-4-methylpyridine-2-carbonitrile

There total 1 articles about 5-Bromo-4-methylpyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-bromo-4-methylpyridine (98198-48-2) → 5-bromo-4-methyl-pyridine-2-carbonitrile (886364-86-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen bromide; bromine; sodium nitrite / water / 1 h / 0 - 5 °C

1.2: 20 °C / pH ~ 13

2.1: n-butyllithium / toluene; pentane / 2 h / -78 °C

2.2: 1 h / -78 °C

2.3: -10 °C

3.1: trichlorophosphate / toluene / 5 h / Heating / reflux

With n-butyllithium; hydrogen bromide; bromine; sodium nitrite; trichlorophosphate; In water; toluene; pentane;

Reference yield:

5-bromo-4-methyl-pyridine-2-carbonitrile (886364-86-9) + 5-chloro-2-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-4-(4,4,5,5-tetramethyl[1,3]dioxolan-2-yl)phenol → 5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile (1070973-08-8)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 16h;

Reference yield:

5-bromo-4-methyl-pyridine-2-carbonitrile (886364-86-9) + 4-chloro-N-(2-hydroxy-phenyl)-N-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (1070892-31-7) → 4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-(2-hydroxy-phenyl)-N-methyl-benzamide (1070889-90-5)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 95 ℃; for 12h;

upstream raw materials:

2-amino-5-bromo-4-methylpyridine

Downstream raw materials:

5-[2-chloro-4-hydroxy-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-4-methyl-pyridine-2-carbonitrile

4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-(2-hydroxy-phenyl)-N-methyl-benzamide

1-(5-bromo-4-methyl-2-pyridyl)ethanone

5-bromo-2-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-4-methyl-pyridine