C₇H₄ClFINO

Base Information

• Chemical Name: C₇H₄ClFINO
• CAS No.: 347185-54-0
• Molecular Formula: C₇H₄ClFINO
• Molecular Weight: 299.471
• Mol file: 347185-54-0.mol

Synonyms:C₇H₄ClFINO

Chemical Property of C₇H₄ClFINO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇H₄ClFINO

There total 6 articles about C₇H₄ClFINO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-3-iodobenzaldehyde oxime (347185-53-9) → C7H4ClFINO (347185-54-0)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 55 ℃; for 0.25h;

Reference yield:

2-fluorobenzonitrile (394-47-8) → C7H4ClFINO (347185-54-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 2,2,6,6-tetramethylpiperidinyl-lithium; iodine / tetrahydrofuran / -78 - 20 °C

2: sulfuric acid / 1,4-dioxane / 115 °C

3: Trimethyl borate; dimethyl sulfide borane / tetrahydrofuran / 0 - 20 °C

4: manganese(IV) oxide / dichloromethane / 50 °C

5: hydroxylamine hydrochloride / ethanol / 20 °C

6: N-chloro-succinimide / N,N-dimethyl-formamide / 55 °C

With manganese(IV) oxide; N-chloro-succinimide; Trimethyl borate; sulfuric acid; hydroxylamine hydrochloride; 2,2,6,6-tetramethylpiperidinyl-lithium; iodine; dimethyl sulfide borane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.09.006

Reference yield:

2-fluoro-3-iodobenzaldehyde (146137-83-9) → C7H4ClFINO (347185-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / ethanol / 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 55 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.09.006

upstream raw materials:

2-fluoro-3-iodobenzaldehyde oxime

2-fluoro-3-iodobenzonitrile

2-fluorobenzonitrile

2-fluoro-3-iodobenzaldehyde

Downstream raw materials:

N-cyclopropyl-2-fluoro-N'-hydroxy-3-iodobenzimidamide