dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

Base Information

Chemical Name:dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate
CAS No.:1316673-74-1
Molecular Formula:C₂₄H₃₁NO₉
Molecular Weight:477.511
Hs Code.:

Synonyms:dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

There total 4 articles about dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1345730-73-5
N-benzylidene-1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-amine N-oxide

: 762-42-5
dimethyl acetylenedicarboxylate

: 1316673-74-1
dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

Guidance literature:: In benzene; at 20 ℃; for 7h; optical yield given as %de; Molecular sieve;
DOI:10.1021/ol201629n

Reference yield:

: 5660-63-9
4,4,5,5-tetramethyl-1,3-dioxolane

: 1316673-74-1
dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylhydroperoxide; 1,10-Phenanthroline; Copper(I); benzoate; sodium hydrogencarbonate / decane; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2: benzene / 7 h / 20 °C / Molecular sieve

With tert.-butylhydroperoxide; 1,10-Phenanthroline; Copper(I); benzoate; sodium hydrogencarbonate; In decane; dimethyl sulfoxide; benzene;
DOI:10.1021/ol201629n

Reference yield:

: 1206188-40-0
C₁₁H₁₃NO₃

: 1316673-74-1
dimethyl 2-(1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-yl)-3-phenyl-2,3-dihydroisoxazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tert.-butylhydroperoxide; 1,10-Phenanthroline; Copper(I); benzoate; sodium hydrogencarbonate / decane; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2: benzene / 7 h / 20 °C / Molecular sieve

With tert.-butylhydroperoxide; 1,10-Phenanthroline; Copper(I); benzoate; sodium hydrogencarbonate; In decane; dimethyl sulfoxide; benzene;
DOI:10.1021/ol201629n