(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

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Chemical Name:(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester
CAS No.:1057653-92-5
Molecular Formula:C₂₃H₂₀N₄O₃
Molecular Weight:400.437
Hs Code.:

Synonyms:(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

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Chemical Property of (1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

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Technology Process of (1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

There total 6 articles about (1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42471-56-7
2-(2-aminobenzoyl)pyridine

: 1057653-92-5
(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 4 h

2: HCl(g) / ethyl acetate / 0.17 h / 23 °C

3: glacial acetic acid, ammonium acetate / 12 h / 23 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, from 0 deg C to RT

With ammonium acetate; hydrogenchloride; sodium hydride; acetic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00078a018

Reference yield:

: 103711-23-5
α-<(tert-butyloxycarbonyl)amino>-N^α-(benzyloxycarbonyl)glycine

: 1057653-92-5
(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.5 h / 0 °C

2: CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 4 h

3: HCl(g) / ethyl acetate / 0.17 h / 23 °C

4: glacial acetic acid, ammonium acetate / 12 h / 23 °C

5: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, from 0 deg C to RT

With 4-methyl-morpholine; ammonium acetate; hydrogenchloride; sodium hydride; acetic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00078a018

Reference yield:

: C₂₀H₂₈N₂O₈

: 1057653-92-5
(1-Methyl-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 4 h

2: HCl(g) / ethyl acetate / 0.17 h / 23 °C

3: glacial acetic acid, ammonium acetate / 12 h / 23 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, from 0 deg C to RT

With ammonium acetate; hydrogenchloride; sodium hydride; acetic acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00078a018