(1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene

Base Information

• Chemical Name: (1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene
• CAS No.: 84810-15-1
• Molecular Formula: C₂₂H₁₈O₃
• Molecular Weight: 330.383
• Mol file: 84810-15-1.mol

Synonyms:(1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene

Chemical Property of (1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene

There total 14 articles about (1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

[2-((Z)-3-Methoxy-1-methyl-2-phenyl-allyl)-phenyl]-phenyl-methanone (118599-43-2) → (1R,3S,4R)-1-Methoxy-4-methyl-1,3-diphenyl-isochroman-3-yl-hydroperoxide (89619-71-6,118599-38-5,118599-45-4) + 1-(2-benzoylphenyl)ethyl phenyl ketone (75519-83-4) + (1S,8R,9S)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.02,7]dodeca-2,4,6-triene (84810-15-1,84847-61-0,118710-98-8,118711-01-6)

Guidance literature:

With ozone; In methanol; dichloromethane; at -70 ℃; Product distribution; Mechanism; other solvents, other temp.;

DOI:10.1021/ja00187a038

Reference yield: 58.0%

methanol (67-56-1) + 1-methyl-2,3-diphenylindene (51310-25-9) → 1-(2-benzoylphenyl)ethyl phenyl ketone (75519-83-4) + (1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.02,7]dodeca-2(7),3,5-triene (84810-15-1) + (1R,8S,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.02,7]dodeca-2(7),3,5-triene (84847-61-0) + (1S,3R,4R)-1-Methoxy-4-methyl-1,3-diphenyl-isochroman-3-yl-hydroperoxide (89619-71-6)

Guidance literature:

With oxygen; ozone; In dichloromethane; at -70 ℃; for 0.5h;

DOI:10.1021/jo00209a028

Reference yield: 45.0%

methanol (67-56-1) + (1R,8S,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.02,7]dodeca-2(7),3,5-triene (84847-61-0) → 1-(2-benzoylphenyl)ethyl phenyl ketone (75519-83-4) + (1R,8R,9R)-8-Methyl-1,9-diphenyl-10,11,12-trioxa-tricyclo[7.2.1.02,7]dodeca-2(7),3,5-triene (84810-15-1)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; at 20 ℃; for 8h; Product distribution; Mechanism; Rate constant;

DOI:10.1021/ja00346a051

upstream raw materials:

[2-((Z)-3-Methoxy-1-methyl-2-phenyl-allyl)-phenyl]-phenyl-methanone

(1R,3S,4R)-1-Methoxy-4-methyl-1,3-diphenyl-isochroman-3-yl-hydroperoxide

1-(2-benzoylphenyl)ethyl phenyl ketone

methanol

Downstream raw materials:

1-(2-benzoylphenyl)ethyl phenyl ketone

Benzoic acid 2-(1-methyl-2-oxo-2-phenyl-ethyl)-phenyl ester

Benzoic acid 2-((Z)-2-hydroxy-1-methyl-2-phenyl-vinyl)-phenyl ester

2-[2-(Hydroxy-phenyl-methyl)-phenyl]-1-phenyl-propan-1-ol