3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

Base Information

Chemical Name:3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole
CAS No.:146885-39-4
Molecular Formula:C₂₈H₂₈N₄OS
Molecular Weight:468.623
Hs Code.:

Synonyms:3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

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Chemical Property of 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

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Technology Process of 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

There total 6 articles about 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 146885-38-3
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(methoxycarbonyl)benzyl>thio>-4H-1,2,4-triazole

: 146885-39-4
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

Guidance literature:: With lithium borohydride; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1021/jm00057a009

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 146885-39-4
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / lithium azide / dimethylsulfoxide / 1 h / Ambient temperature

2: triphenylphosphine / 5.5 h / Ambient temperature

3: hydrazine hydrate / tetrahydrofuran / 0.17 h

4: 64 percent / 2-methoxy-ethanol / 4 h / Heating

5: 76 percent / N,N-diisopropylethylamine / 2-methoxy-ethanol / 3.5 h / Ambient temperature

6: 32 percent / lithium borohydride / tetrahydrofuran / 24 h / Ambient temperature

With lithium borohydride; lithium azide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00057a009

Reference yield:

: 133690-91-2
4'-(azidomethyl)[1,1'-biphenyl]-2-carbonitrile

: 146885-39-4
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-5-<<2-(hydroxymethyl)benzyl>thio>-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / 5.5 h / Ambient temperature

2: hydrazine hydrate / tetrahydrofuran / 0.17 h

3: 64 percent / 2-methoxy-ethanol / 4 h / Heating

4: 76 percent / N,N-diisopropylethylamine / 2-methoxy-ethanol / 3.5 h / Ambient temperature

5: 32 percent / lithium borohydride / tetrahydrofuran / 24 h / Ambient temperature

With lithium borohydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol;
DOI:10.1021/jm00057a009