C₁₉H₂₂O₃

Base Information

• Chemical Name: C₁₉H₂₂O₃
• CAS No.: 1277176-10-9
• Molecular Formula: C₁₉H₂₂O₃
• Molecular Weight: 298.382
• Mol file: 1277176-10-9.mol

Synonyms:C₁₉H₂₂O₃

Chemical Property of C₁₉H₂₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₂O₃

There total 4 articles about C₁₉H₂₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-ethynyl-2,4-dihydroxy-3-methylbenzaldehyde (915789-22-9) + C9H15I → C19H22O3 (1277176-10-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo102448n

Reference yield:

C10H11IO3 → C19H22O3 (1277176-10-9)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 18 h / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate / dichloromethane / 13 h / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron tribromide; potassium carbonate; triethylamine; diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; dichloromethane; 3: Sonogashira coupling;

DOI:10.1021/jo102448n

Reference yield:

2-iodo-4,6-dihydroxy-5-methylbenzaldehyde (1277176-12-1) → C19H22O3 (1277176-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate / dichloromethane / 13 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; diisopropylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; dichloromethane; 2: Sonogashira coupling;

DOI:10.1021/jo102448n

upstream raw materials:

6-ethynyl-2,4-dihydroxy-3-methylbenzaldehyde

2-iodo-4,6-dihydroxy-5-methylbenzaldehyde

2,4-dimethoxy-3-methylbenzaldehyde

Downstream raw materials:

7-epi-sclerotiorin

sclerotioramine