Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

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Chemical Name:Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine
CAS No.:305838-46-4
Molecular Formula:C₃₀H₄₇NO₅Si
Molecular Weight:529.792
Hs Code.:

Synonyms:Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

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Chemical Property of Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

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Technology Process of Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

There total 3 articles about Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107-30-2
chloromethyl methyl ether

: 305838-42-0
(2S,3R)-1-(tert-butyldimethylsilanyloxy)-2-dibenzylamino-5-[1,3]dioxolan-2-yl-pentan-3-ol

: 305838-46-4
Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4039(00)01207-7

Reference yield:

: 125654-82-2
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

: 305838-46-4
Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran

1.2: tetrahydrofuran

2.1: 90 percent / (iPr)2EtN / CH₂Cl₂ / 20 °C

With magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution;
DOI:10.1016/S0040-4039(00)01207-7

Reference yield:

: 239437-14-0
N,N-dibenzyl-O-tert-butyldimethylsilyl serinol

: 305838-46-4
Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-2-methoxymethoxy-butyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

2.1: Mg / tetrahydrofuran

2.2: tetrahydrofuran

3.1: 90 percent / (iPr)2EtN / CH₂Cl₂ / 20 °C

With oxalyl dichloride; magnesium; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1.1: Oxidation / 2.1: Metallation / 2.2: Grignard reaction / 3.1: Substitution;
DOI:10.1016/S0040-4039(00)01207-7