6,7-DIFLUOROISATOIC ANHYDRIDE

Base Information

• Chemical Name: 6,7-DIFLUOROISATOIC ANHYDRIDE
• CAS No.: 97927-59-8
• Molecular Formula: C8H3 F2 N O3
• Molecular Weight: 199.114
• Hs Code.: 2934999090
• Mol file: 97927-59-8.mol

Synonyms:4,5-Difluoroisatoicanhydride; 6,7-Difluoro-1H-benzo[d][1,3]oxazine-2,4-dione;6,7-Difluoro-2H-3,1-benzoxazine-2,4(1H)-dione

Chemical Property of 6,7-DIFLUOROISATOIC ANHYDRIDE

Chemical Property:

• PSA: 63.07000
• LogP: 0.75950
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4,5-DifluoroisatoicAnhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-DIFLUOROISATOIC ANHYDRIDE

There total 5 articles about 6,7-DIFLUOROISATOIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butoxycarbonylamino)-4,5-difluorobenzoic acid (226250-01-7) → 6,7-difluoro-2H-3,1-benzoxazine-2,4(1H)-dione (97927-59-8)

Guidance literature:

2-(tert-butoxycarbonylamino)-4,5-difluorobenzoic acid; With 2-chloro-1-methyl-pyridinium iodide; In acetonitrile; at 20 ℃; for 0.166667h;

With hydrogenchloride; In water; acetonitrile;

DOI:10.1016/j.tetlet.2013.10.034

Reference yield:

phosgene (75-44-5) + 2-amino-4,5-difluorobenzoic acid (83506-93-8) → 6,7-difluoro-2H-3,1-benzoxazine-2,4(1H)-dione (97927-59-8)

Guidance literature:

In water; sodium carbonate; toluene;

Reference yield:

2-amino-4,5-difluorobenzoic acid (83506-93-8) → 6,7-difluoro-2H-3,1-benzoxazine-2,4(1H)-dione (97927-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / acetonitrile / 2 h / 20 °C

2: 2-chloro-1-methyl-pyridinium iodide / acetonitrile / 0.17 h / 20 °C

With dmap; 2-chloro-1-methyl-pyridinium iodide; triethylamine; In acetonitrile;

DOI:10.1016/j.tetlet.2013.10.034

upstream raw materials:

2-amino-4,5-difluorobenzoic acid

1,1'-carbonyldiimidazole

phosgene

2-(tert-butoxycarbonylamino)-4,5-difluorobenzoic acid

Downstream raw materials:

1-benzyl-3-tert-butoxy-6-fluoro-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione

1-benzyl-3-tert-butoxy-6,7-difluoro-1H-quinazoline-2,4-dione

6,7-difluoro-3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4(1H)-one

3-benzyl-7,8-difluoro-1-methyl-3,4-dihydro-1H-benzo[d][1,3]diazepine-5(2H)-one

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