2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

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Chemical Name:2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one
CAS No.:130065-32-6
Molecular Formula:C₂₄H₄₁N₃O₆Si₂
Molecular Weight:523.777
Hs Code.:

Synonyms:2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

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Chemical Property of 2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

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Technology Process of 2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

There total 5 articles about 2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2-(Trimethylsilyl)ethyl azidoformate

: 130065-31-5
4-<2'-<(tert-Butyldimethylsilyl)oxy>ethyl>-1-(o-nitrobenzyl)pyrazolidin-3-one

: 130065-32-6
2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1) 0 deg C, 2) r.t.;
DOI:10.1021/jo00311a023

Reference yield:

: 98837-36-6,111002-28-9,112572-93-7,18020-65-0
methyl 3-hydroxy-2-methylenebutyrate

: 130065-32-6
2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / methanol / 4 h / Heating

2: Et₃N, NaI / dimethylformamide / Ambient temperature

3: 2.59 g / imidazole / dimethylformamide / 24 h / Ambient temperature

4: 64 percent / 60percent NaH / tetrahydrofuran / 1) 0 deg C, 2) r.t.

With 1H-imidazole; sodium hydride; hydrazine hydrate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a023

Reference yield:

: (S)-4-((R)-1-Hydroxy-ethyl)-1-(2-nitro-benzyl)-pyrazolidin-3-one

: 130065-32-6
2-<2-(Trimethylsilyl)ethoxycarbonyl>-1-(o-nitrobenzyl)-4-<2'-<(tert-butyldimethylsilyl)oxy>ethyl>pyrazolidin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 2.59 g / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 64 percent / 60percent NaH / tetrahydrofuran / 1) 0 deg C, 2) r.t.

With 1H-imidazole; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00311a023