Technology Process of C12H18N4O
There total 5 articles about C12H18N4O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium formate;
1% Pd/C;
In
ethanol; water;
for 2.01667h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 2 h / Reflux
2: ammonia / dichloromethane
3: potassium carbonate / dimethyl sulfoxide / 1 h / 60 °C
4: palladium 10% on activated carbon; hydrogen / ethanol
With
thionyl chloride; palladium 10% on activated carbon; ammonia; hydrogen; potassium carbonate;
In
ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.0c01374
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sulfuric acid; nitric acid / 1 h / 0 - 20 °C
2: thionyl chloride / 2 h / Reflux
3: ammonia / dichloromethane
4: potassium carbonate / dimethyl sulfoxide / 1 h / 60 °C
5: palladium 10% on activated carbon; hydrogen / ethanol
With
thionyl chloride; sulfuric acid; palladium 10% on activated carbon; ammonia; hydrogen; nitric acid; potassium carbonate;
In
ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.0c01374