O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

Base Information

Chemical Name:O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate
CAS No.:1361338-48-8
Molecular Formula:C₁₅H₁₁F₂IN₂O₄S₃
Molecular Weight:544.363
Hs Code.:

Synonyms:O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

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Chemical Property of O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

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Technology Process of O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

There total 4 articles about O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361336-38-0
1-(2,2-difluoroethyl)-3-(2-iodophenyl)-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-ol 2,2-dioxide

: 18369-83-0
methyl thiochloroformate

: 1361338-48-8
O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1361340-65-9
methyl 4-{[(2-iodobenzyl)sulfonyl]amino}-1,3-thiazole-5-carboxylate

: 1361338-48-8
O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

2.2: pH 4 - 5

3.1: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 25068-94-4
(2-iodo-phenyl)-methanesulfonyl chloride

: 1361338-48-8
O-[1-(2,2-difluoroethyl)-3-(2-iodophenyl)-2,2-dioxido-1H-[1,3]thiazolo[4,5-c][1,2]thiazin-4-yl] S-methyl thiocarbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

3.2: pH 4 - 5

4.1: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;