18369-83-0

Basic information

• Product Name: METHYL CHLOROTHIOLFORMATE
• Synonyms: carbonochloridothioicacid,s-methylester;chloro-thioformicacimethylester;chlorothio-formicacis-methylester;Formic acid, chlorothio-, S-methyl ester;Methyl chlorothioformate;Methyl thiochloroformate;Methyl thiolchloroformate;methylchlorothioformate
• CAS NO: 18369-83-0
• Molecular Formula: C₂H₃ClOS
• Molecular Weight: 110.56
• EINECS: 242-244-2
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds
• Mol File: 18369-83-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 110 °C(lit.)
• Flash Point: 88 °F
• Appearance: /
• Density: 1.288 g/mL at 25 °C(lit.)
• Vapor Pressure: 26.9mmHg at 25°C
• Refractive Index: n20/D 1.49(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL CHLOROTHIOLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL CHLOROTHIOLFORMATE(18369-83-0)
• EPA Substance Registry System: METHYL CHLOROTHIOLFORMATE(18369-83-0)

Safety Data

• Hazard Codes: C
• Statements: 10-20/21/22-34-52/53
• Safety Statements: 16-26-27-36/37/39-45-61
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• RTECS: LQ7000000
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 18369-83-0(Hazardous Substances Data)

Usage

Uses

Methyl Chlorothioformate is a chemical reagent used in the synthesis of Mitomycin C (M371900)-tethered phosphorothiaoate oligodeoxynucleotides. for use as an anti-tumor antibiotic. Also used in the preparation of Brassinin (B676950) derivatives, a plant metabolite of great significance due to its dual role both as an effective phytoalexin and as an early biosynthetic precursor of the majority of the phytoalexins.

InChI:InChI=1/C2H3ClOS/c1-5-2(3)4/h1H3

Upstream product

• 2812-72-8 methyl chlorothioformate 
• 353-49-1 fluoroformyl chloride 
• 67-68-5 dimethyl sulfoxide 
• 75-44-5 phosgene 
• 7446-70-0 aluminium trichloride 
• 74-93-1 methylthiol 

Downstream Products

• 51861-05-3 S-Methyl N-cyclohexyl(thiocarbamate) 
• 39248-75-4 methyl m-xylenethiocarboxylate 
• 5925-77-9 S-methyl 4-methylbenzothioate 
• 91133-79-8 S-Methyl-N-<4-ethoxycarbonyl-phenyl>-thiolcarbamat 
• 39274-34-5 methyl cumenethiocarboxylate 
• 701-50-8 methyl fluorobenzenethiocarboxylate 
• 4906-32-5 methyl bromobenzenethiocarboxylate 
• 39274-35-6 4-tert-Butyl-thiobenzoesaeure-S-methylester 
• 3326-53-2 Diphenylmethyl-methyl-thiocarbonat 
• 39248-83-4 S-methyl p-iodobenzothioate 
• 39274-36-7 3,4-Dimethyl-thiobenzoesaeure-methylester 
• 39251-06-4 4-Ethylthiobenzoesaeure-methylester 
• 39248-79-8 2,3,5,6-Tetramethyl-thiobenzoesaeure-methylester 
• 39248-80-1 Pentamethylthiobenzoesaeure-methylester 

Relevant articles and documents

Synthesis of amides from Glycosmis species: Methylthiopropenoic acid, methylsulfonylpropenoic acid, thiocarbamic acid S-methyl ester, and senecioic acid amides

Representative samples of several types of naturally occurring amides from south and southeast Asian Glycosmis species were synthesized for proof of structures and for bioactivity testing. With one exception (senecioic acid) all these amides were characterized by sulfur containing acid components (methylthiopropenoic acid, methylsulfonylpropenoic acid, and thiocarbamic acid) in combination with phenethylamine derived amino moieties.

NOVEL SYNTHESIS OF DISUBSTITUTED THIOLCARBAMATES VIA A SULFUR TRANSFER AGENT-POTASSIUM ALKYL OR BENZYL DITHIOCARBONATES

The reaction of N,N-disubstituted carbamoyl chlorides with potassium alkyl or benzyl dithiocarbonates afforded a novel synthesis of disubstituted thiolcarbamates.