N-(2-chloro-4,6-dimethylphenyl)acetamide

Base Information

• Chemical Name: N-(2-chloro-4,6-dimethylphenyl)acetamide
• CAS No.: 93506-80-0
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50568069
• Nikkaji Number: J37.720A
• Wikidata: Q72518638
• Mol file: 93506-80-0.mol

Synonyms:93506-80-0;N-(2-chloro-4,6-dimethylphenyl)acetamide;2-Chloro-4,6-dimethyl acetanilide;2'-Chloro-4',6'-dimethylacetanilide;SCHEMBL15765839;DTXSID50568069;RDPQJNWJMMXTKB-UHFFFAOYSA-N;AKOS002958995;N-(2-chloro-4,6-dimethyl-phenyl)-acetamide

Chemical Property of N-(2-chloro-4,6-dimethylphenyl)acetamide

Chemical Property:

• Melting Point: 201-202 °C
• Boiling Point: 324.735 °C at 760 mmHg
• Flash Point: 150.195 °C
• PSA: 29.10000
• Density: 1.183 g/cm³
• LogP: 2.98820
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 197.0607417
• Heavy Atom Count: 13
• Complexity: 195

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-4,6-DIMETHYL ACETANILIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)Cl)NC(=O)C)C

Technology Process of N-(2-chloro-4,6-dimethylphenyl)acetamide

There total 5 articles about N-(2-chloro-4,6-dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2,4-dimethylphenyl)acetamide (2050-43-3) → 2-chloro-4,6-dimethyl-acetanilide (93506-80-0)

Guidance literature:

With chlorine; iron(III) chloride; acetic acid;

DOI:10.1021/ja01162a026

Reference yield:

2,4-Xylidine (95-68-1) → 2-chloro-4,6-dimethyl-acetanilide (93506-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl; sodium acetate

2: FeCl₃; acetic acid; chlorine

With hydrogenchloride; sodium acetate; chlorine; iron(III) chloride; acetic acid;

DOI:10.1021/ja01162a026

Reference yield:

N-(2,4-dimethylphenyl)acetamide (2050-43-3) + acetic acid-(2,4,N-trichloro-anilide) (112160-74-4) → 2-chloro-4,6-dimethyl-acetanilide (93506-80-0)

Guidance literature:

With hydrogenchloride; acetic acid;

upstream raw materials:

N-(2,4-dimethylphenyl)acetamide

acetic acid-(2,4,N-trichloro-anilide)

hydrogenchloride

acetic acid

Downstream raw materials:

2-chloro-4,6-dimethylaniline