tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate
CAS No.:1566544-44-2
Molecular Formula:C₃₂H₃₃F₃N₆O₃
Molecular Weight:606.648
Hs Code.:

Synonyms:tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1566543-58-5
tert-butyl 4-(5-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

: 1566543-59-6
1-(2-ethynyl phenyl)cyclopropanecarboxamide

: 1566544-44-2
tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In 1,4-dioxane; at 85 ℃; for 4h;

Reference yield:

: 885693-47-0
tert-butyl 5-nitro-5’,6’-dihydro-[2,4‘-bipyridine]-1‘(2’H)-carboxylate

: 1566544-44-2
tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.33 h / 20 °C

2.2: 44 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 4 h / 85 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; zinc(II) chloride; In 1,4-dioxane; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 885693-48-1
5-amino-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridinyl)-1'-carboxylic acid tert-butyl ester

: 1566544-44-2
tert-butyl 4-(5-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)pyridin-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.33 h / 20 °C

1.2: 44 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / 1,4-dioxane / 4 h / 85 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; zinc(II) chloride; In 1,4-dioxane; diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol;