5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile

Base Information

• Chemical Name: 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile
• CAS No.: 931410-13-8
• Molecular Formula: C₃₃H₃₀N₂O₃
• Molecular Weight: 502.613
• Mol file: 931410-13-8.mol

Synonyms:5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile

Chemical Property of 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile

There total 6 articles about 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(4-cyano-4,4-diphenylbutanoyl)azetidin-3-yl methansulfonate (931410-12-7) + O-benzylcatechol (6272-38-4) → 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile (931410-13-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/jm200884j

Reference yield: 77.0%

→ 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile (931410-13-8)

Guidance literature:

Reference yield:

tert-butyl 4-cyano-4,4-diphenylbutanoate (931409-69-7) → 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile (931410-13-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

4: potassium carbonate / acetonitrile / 3.5 h / 80 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/jm200884j

upstream raw materials:

tert-butyl 4-cyano-4,4-diphenylbutanoate

1-(4-cyano-4,4-diphenylbutanoyl)azetidin-3-yl methansulfonate

O-benzylcatechol

Diphenylacetonitrile

Downstream raw materials:

5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile