5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile

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Chemical Name:5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile
CAS No.:931410-14-9
Molecular Formula:C₃₅H₃₆N₂O₂
Molecular Weight:516.683
Hs Code.:

Synonyms:5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile

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Chemical Property of 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile

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Technology Process of 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile

There total 2 articles about 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 676-58-4
methylmagnesium chloride

: 931410-14-9
5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile; With zirconium(IV) chloride; In tetrahydrofuran; at -35 ℃; for 1h;

methylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 3h;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield: 10.0%

: 931410-13-8
5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile

: 676-58-4
methylmagnesium chloride

: 931410-14-9
5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-methyl-2,2-diphenylhexanenitrile

Guidance literature:: 5-{3-[2-(benzyloxy)phenoxy]azetidin-1-yl}-5-oxo-2,2-diphenylpentanenitrile; With zirconium(IV) chloride; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

methylmagnesium chloride; In tetrahydrofuran; at -20 - -10 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm200884j