1-methyl-4-[(R)-1-methylallyl]benzene

Base Information

• Chemical Name: 1-methyl-4-[(R)-1-methylallyl]benzene
• CAS No.: 72782-48-0
• Molecular Formula: C₁₁H₁₄
• Molecular Weight: 146.232
• Mol file: 72782-48-0.mol

Synonyms:1-methyl-4-[(R)-1-methylallyl]benzene

Chemical Property of 1-methyl-4-[(R)-1-methylallyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-4-[(R)-1-methylallyl]benzene

There total 10 articles about 1-methyl-4-[(R)-1-methylallyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + ethene (74-85-1) → 1-methyl-4-[(R)-1-methylallyl]benzene (72782-48-0) + 1-methyl-4-[(1S)-1-methylprop-2-en-1-yl]benzene (77693-46-0)

Guidance literature:

With bi(allylnickel bromide); chiral phospholane ligand; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at -55 ℃; for 2h; under 760 Torr; Title compound not separated from byproducts;

DOI:10.1021/ol048790v

Reference yield:

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + carbon monoxide (201230-82-2) → 1-methyl-4-[(R)-1-methylallyl]benzene (72782-48-0) + 1-methyl-4-[(1S)-1-methylprop-2-en-1-yl]benzene (77693-46-0)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); 5,10,15,20-tetraphenylporphyrinato ruthenium carbonyl; C₄₉H₄₃N₃O₂P₂; hydrogen; In toluene; at 25 ℃; for 84h; under 15001.5 Torr; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201202044

Reference yield:

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + ethene (74-85-1) → 1-methyl-4-[(R)-1-methylallyl]benzene (72782-48-0) + α,β,p-trimethylstyrene (81676-11-1) + 1-methyl-4-[(1S)-1-methylprop-2-en-1-yl]benzene (77693-46-0)

Guidance literature:

With [(R)-1,1'-spirobiindane-7,7'-diyl] diisopropylamidophosphite; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; In toluene; at 25 ℃; for 1h; under 750.06 Torr; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2004.12.017

upstream raw materials:

Vinyl bromide

1-(p-tolyl)ethylmagnesium chloride

1-ethenyl-4-methylbenzene

ethene

Downstream raw materials:

(R)-(-)-α-curcumene

(R)-3-(4-methylphenyl)-1-butanol

(R)-3-(4-methylphenyl)butanal

(R)-2-methyl-6-(4-methylphenyl)-2-hepten-4-one

Refernces

• 1、 Grassi, David,Dolka, Chrysanthi,Jackowski, Olivier,Alexakis, Alexandre. "Copper-free asymmetric allylic alkylation with a grignard reagent: Design of the ligand and mechanistic studies". supporting information. p. 1466 - 1475. Retrieved 2013/02/25.
• 2、 Jiang, Gaoxi,List, Benjamin. "Enantioselective hydrovinylation via asymmetric counteranion-directed ruthenium catalysis". supporting information; experimental part. p. 10022 - 10024. Retrieved 2011/10/12.