methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

Base Information

Chemical Name:methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate
CAS No.:140195-94-4
Molecular Formula:C₂₁H₂₂N₂O₅
Molecular Weight:382.416
Hs Code.:

Synonyms:methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

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Chemical Property of methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

Chemical Property:

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Technology Process of methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

There total 4 articles about methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: methyl 1-azido-t-2-phenyl-r-1-cyclopropanecarboxylate

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 140195-94-4
methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

Guidance literature:: With tributylphosphine; diphenyl diselenide; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)77720-3

Reference yield:

: 81777-11-9
(Z)-methyl 2-azido-3-phenylacrylate

: 140195-94-4
methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / diethyl ether / 48 h / Ambient temperature

2: 35 percent / CCl₄ / 3.5 h / 80 °C

3: 1.) tributylphosphine, diphenyldiselenide, 2.) HOBt / 1.) CH₂Cl₂, DMF, RT, 2.) CH₂Cl₂, DMF, overnight

With tributylphosphine; diphenyl diselenide; benzotriazol-1-ol; In tetrachloromethane; diethyl ether;
DOI:10.1246/bcsj.69.1705

Reference yield:

: 100-52-7
benzaldehyde

: 140195-94-4
methyl DL-1-(N-benzyloxycarbonylglycylamino)-t-2-phenyl-r-1-cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / sodium methoxide / methanol / 1.) 10 deg C, 20 min, 2.) 25 deg C, 3 h

2: 100 percent / diethyl ether / 48 h / Ambient temperature

3: 35 percent / CCl₄ / 3.5 h / 80 °C

4: 1.) tributylphosphine, diphenyldiselenide, 2.) HOBt / 1.) CH₂Cl₂, DMF, RT, 2.) CH₂Cl₂, DMF, overnight

With tributylphosphine; diphenyl diselenide; sodium methylate; benzotriazol-1-ol; In methanol; tetrachloromethane; diethyl ether;
DOI:10.1246/bcsj.69.1705