6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Base Information

Chemical Name:6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide
CAS No.:342416-97-1
Molecular Formula:C₁₉H₂₆N₄O
Molecular Weight:326.442
Hs Code.:

Synonyms:6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Suppliers and Price of 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

There total 5 articles about 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 109-01-3
1-methyl-piperazine

: 33872-80-9
o-tolyl magnesium chloride

: 54189-82-1
6-chloro-N-methylnicotinamide

: 342416-97-1
6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Guidance literature:: o-tolyl magnesium chloride; 6-chloro-N-methylnicotinamide; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

1-methyl-piperazine; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1021/jo0523666

Reference yield:

: 109-01-3
1-methyl-piperazine

: 6-chloro-N-methylnicotinamide

: 33872-80-9
o-tolyl magnesium chloride

: ammonium chloride

: 342416-97-1
6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Guidance literature:: With sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 342416-97-1
6-(4-methylpiperazin-1-yl)-4-(o-tolyl)-4,5-dihydropyridine-3-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 8.9 g / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2.1: tetrahydrofuran / 1.5 h / 0 - 20 °C

2.2: 94 percent / tetrahydrofuran / 2.5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane; 2.1: Grignard addition;
DOI:10.1021/jo0523666