Technology Process of 7α-chloro-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one
There total 1 articles about 7α-chloro-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 98 percent / tert-butylhydroperoxide, VO(C5H7O2)2 / toluene / 2 h / 80 °C
2: 79 percent / P(C6H5)3 / CCl4; CH2Cl2; pyridine / 2 h / 0 deg C to room temp.
With
tert.-butylhydroperoxide; VO(C5H7O2)2; triphenylphosphine;
In
pyridine; tetrachloromethane; dichloromethane; toluene;
- Guidance literature:
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Multi-step reaction with 4 steps
1: 75 percent / Zn / acetic anhydride; tetrahydrofuran / 1.5 h / 70 °C
2: 94 percent / KOH, NaClO4 / tetrahydrofuran; methanol / 2.5 h / Ambient temperature
3: 88 percent / Zn/Cu / 1,2-dimethoxy-ethane / 5 h / 55 °C
4: 69 percent / KOEt / tetrahydrofuran / 2 h / Ambient temperature
With
potassium hydroxide; potassium ethoxide; sodium perchlorate; copper; zinc;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; acetic anhydride;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 75 percent / Zn / acetic anhydride; tetrahydrofuran / 1.5 h / 70 °C
2: 94 percent / KOH, NaClO4 / tetrahydrofuran; methanol / 2.5 h / Ambient temperature
3: 88 percent / Zn/Cu / 1,2-dimethoxy-ethane / 5 h / 55 °C
4: 69 percent / KOEt / tetrahydrofuran / 2 h / Ambient temperature
5: 95 percent / H2 / Pd/CaCO3 / tetrahydrofuran; propan-2-ol / 2 h / 750.06 Torr / Ambient temperature
6: 62 percent / pyridinium dichromate / dimethylformamide / 24 h / 70 °C
7: 59 percent / DDQ / dioxane / 1.5 h / 100 °C
With
potassium hydroxide; dipyridinium dichromate; potassium ethoxide; sodium perchlorate; hydrogen; copper; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc;
Lindlar's catalyst;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; acetic anhydride; N,N-dimethyl-formamide; isopropyl alcohol;
