1,3,7-trimethyl-8-(p-bromophenyl)-xanthine

Base Information

• Chemical Name: 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine
• CAS No.: 1352798-38-9
• Molecular Formula: C₁₄H₁₃BrN₄O₂
• Molecular Weight: 349.187
• Mol file: 1352798-38-9.mol

Synonyms:1,3,7-trimethyl-8-(p-bromophenyl)-xanthine

Chemical Property of 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine

There total 3 articles about 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (58-08-2,138455-22-8,95789-13-2) + sodium 4-bromobenzenesulfinate (34176-08-4) → 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine (1352798-38-9)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; copper diacetate; In 1,4-dioxane; dimethyl sulfoxide; at 20 - 110 ℃; for 24.08h; Inert atmosphere;

DOI:10.1002/chem.201102644

Reference yield: 89.0%

p-bromophenylsulfonyl hydrazide (2297-64-5) + 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (58-08-2,138455-22-8,95789-13-2) → 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine (1352798-38-9)

Guidance literature:

With copper diacetate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201201450

Reference yield:

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (58-08-2,138455-22-8,95789-13-2) + 4-bromo-aniline (106-40-1) → 1,3,7-trimethyl-8-(p-bromophenyl)-xanthine (1352798-38-9)

Guidance literature:

4-bromo-aniline; With tetrafluoroboric acid; sodium nitrite; In water; at 0 ℃; Inert atmosphere;

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; With tris(bipyridine)ruthenium(II) dichloride hexahydrate; In formic acid; water; at 25 ℃; for 24h; Catalytic behavior; Irradiation; Inert atmosphere;

DOI:10.1002/chem.201304120

upstream raw materials:

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

sodium 4-bromobenzenesulfinate

p-bromophenylsulfonyl hydrazide

4-bromo-aniline

Refernces

• 1、 Liu, Bo,Li, Jian,Song, Feijie,You, Jingsong. "Palladium-catalyzed direct arylation of N-heteroarenes with arylsulfonyl hydrazides". supporting information; experimental part. p. 10830 - 10833. Retrieved 2012/09/22.