4-(2-Methoxy-phenyl)-thiazol-2-ylamine

Base Information

• Chemical Name: 4-(2-Methoxy-phenyl)-thiazol-2-ylamine
• CAS No.: 93209-95-1
• Molecular Formula: C10H10 N2 O S
• Molecular Weight: 206.268
• Hs Code.: 2934100090
• European Community (EC) Number: 675-473-5
• DSSTox Substance ID: DTXSID40352752
• Nikkaji Number: J2.570.248D
• Wikidata: Q82130063
• ChEMBL ID: CHEMBL2297470
• Mol file: 93209-95-1.mol

Synonyms:93209-95-1;4-(2-Methoxy-phenyl)-thiazol-2-ylamine;4-(2-methoxyphenyl)-1,3-thiazol-2-amine;4-(2-methoxyphenyl)thiazol-2-amine;MFCD01535790;4-(2-methoxyphenyl)thiazol-2-ylamine;thiazol-2-amine, 15;Oprea1_339109;SCHEMBL234658;IFLab1_000177;CHEMBL2297470;BDBM31195;DTXSID40352752;DVVAVWNGAFFCNW-UHFFFAOYSA-N;HMS1412I01;4-(o-methoxyphenyl)-2-aminothiazole;BBL012688;STL163657;AKOS000112459;IDI1_008396;AS-42799;BB 0217950;CS-0117222;FT-0677750;EN300-37442;SR-01000391193;SR-01000391193-1;Z48847513;F0007-1007

Chemical Property of 4-(2-Methoxy-phenyl)-thiazol-2-ylamine

Chemical Property:

• PSA: 76.38000
• LogP: 2.98210
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.05138412
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-methoxyphenyl)thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=CSC(=N2)N

Technology Process of 4-(2-Methoxy-phenyl)-thiazol-2-ylamine

There total 5 articles about 4-(2-Methoxy-phenyl)-thiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-diazo-1-(2-methoxyphenyl)ethanone (7169-17-7) + thiourea (17356-08-0) → 2-amino-4-(2-methoxyphenyl)-1,3-thiazole (93209-95-1)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 80 ℃; for 2.5h;

DOI:10.1016/j.tetlet.2008.02.068

Reference yield: 93.0%

2-Methoxyacetophenone (579-74-8) + thiourea (17356-08-0) → 2-amino-4-(2-methoxyphenyl)-1,3-thiazole (93209-95-1)

Guidance literature:

With carbon tetrabromide; triethylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2015.08.064

Reference yield: 60.0%

bromomethyl 2-methoxyphenyl ketone (31949-21-0) + potassium thioacyanate (333-20-0) → 2-amino-4-(2-methoxyphenyl)-1,3-thiazole (93209-95-1)

Guidance literature:

With aluminum oxide; ammonium acetate; silica gel; In benzene; at 90 ℃; for 16h;

DOI:10.1016/j.bmc.2003.10.041

upstream raw materials:

2-Methoxyacetophenone

thiourea

bromomethyl 2-methoxyphenyl ketone

potassium thioacyanate

Downstream raw materials:

C₂₁H₁₆N₂O₂S

C₁₇H₁₃BrN₂O₂S

C₁₈H₁₆N₂O₃S

C₁₈H₁₆N₂O₂S