methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

Base Information

Chemical Name:methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate
CAS No.:1449374-41-7
Molecular Formula:C₂₉H₂₅Cl₂N₃O₃
Molecular Weight:534.442
Hs Code.:

Synonyms:methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

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Chemical Property of methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

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Technology Process of methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

There total 5 articles about methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2894-51-1
2-amino-4'-chlorobenzophenone

: 1449374-41-7
methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation; Molecular sieve

2.1: potassium hydroxide / water; ethanol / 0.75 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrazine / ethanol / 0.33 h / 110 °C / Microwave irradiation

4.1: boron containing reagent / 4 h / 20 °C

With potassium hydroxide; hydrazine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400652r

Reference yield:

: 118-48-9
isatoic anhydride

: 1449374-41-7
methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 0.17 h

1.2: 2 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 0.5 h / 160 °C / Microwave irradiation; Molecular sieve

4.1: potassium hydroxide / water; ethanol / 0.75 h / 0 °C

4.2: 0 - 20 °C

5.1: hydrazine / ethanol / 0.33 h / 110 °C / Microwave irradiation

6.1: boron containing reagent / 4 h / 20 °C

With n-butyllithium; triethylamine; potassium hydroxide; hydrazine; In tetrahydrofuran; ethanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400652r

Reference yield:

: 313398-25-3
3-acetyl-4-(4-chlorophenyl)quinolin-2(1H)-one

: 1449374-41-7
methyl 4-{5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water; ethanol / 0.75 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrazine / ethanol / 0.33 h / 110 °C / Microwave irradiation

3.1: boron containing reagent / 4 h / 20 °C

With potassium hydroxide; hydrazine; In ethanol; water;
DOI:10.1021/jm400652r