N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Base Information

Chemical Name:N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide
CAS No.:796863-98-4
Molecular Formula:C₂₂H₂₈N₂O₄
Molecular Weight:384.475
Hs Code.:

Synonyms:N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

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Chemical Property of N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

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Technology Process of N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

There total 5 articles about N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 796863-79-1
N-[5-ethyl-4-(3-formylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

: 796863-98-4
N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 5 ℃; for 2h;
DOI:10.1021/jm0407658

Reference yield:

: 68348-23-2
3-(1,3-dioxolan-2-yl)benzaldehyde

: 796863-98-4
N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 73 percent / tri[2-(2-methoxyethoxy)ethyl]amine; KMnO₄ / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / aq. HCl / 1 h / 20 °C

4.1: 46 percent / sodium borohydride / methanol / 2 h / 5 °C

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm0407658

Reference yield:

: 197229-98-4
5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine

: 796863-98-4
N-[5-ethyl-4-(3-hydroxymethylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 73 percent / tri[2-(2-methoxyethoxy)ethyl]amine; KMnO₄ / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / aq. HCl / 1 h / 20 °C

4.1: 46 percent / sodium borohydride / methanol / 2 h / 5 °C

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Tris(3,6-dioxaheptyl)amine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm0407658