(Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone

Base Information

• Chemical Name: (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone
• CAS No.: 1359978-79-2
• Molecular Formula: C₁₉H₁₄F₆OS
• Molecular Weight: 404.376

Synonyms:(Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone

Chemical Property of (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone

Chemical Property:

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Technology Process of (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone

There total 2 articles about (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2'-(methylthio)acetophenone (1441-97-0) + 3,5-bis(trifluoromethyl)phenylacetylene (88444-81-9) → (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone (1359978-79-2)

Guidance literature:

With [Rh(κ2P,P-DPEphos)(ν6-o-xylene)][BArF4]; In o-xylene; at 60 ℃; for 4h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja2108992

Reference yield:

1-(2-chlorophenyl)ethanone (2142-68-9) → (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone (1359978-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2: [Rh(κ2P,P-DPEphos)(ν6-o-xylene)][BArF4] / o-xylene / 4 h / 60 °C / Inert atmosphere

With [Rh(κ2P,P-DPEphos)(ν6-o-xylene)][BArF4]; In o-xylene; N,N-dimethyl-formamide;

DOI:10.1021/ja2108992

Reference yield: 66.0%

(Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone (1359978-79-2) + toluene-4-sulfonic acid hydrazide (1576-35-8) → (E)-N'-(1-(2-((Z)-2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide (1359978-77-0)

Guidance literature:

With acetic acid; In ethanol; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ja2108992

upstream raw materials:

1-(2-chlorophenyl)ethanone

2'-(methylthio)acetophenone

3,5-bis(trifluoromethyl)phenylacetylene

Downstream raw materials:

(E)-N'-(1-(2-((Z)-2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide

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