1441-97-0

Basic information

• Product Name: o-(Methylthio)acetophenone
• Synonyms: 1-[2-(Methylthio)phenyl]ethanone;2'-(Methylthio)acetophenone;o-(Methylthio)acetophenone;1-(2-(methylthio)phenyl)ethan-1-one
• CAS NO: 1441-97-0
• Molecular Formula: C₉H₁₀OS
• Molecular Weight: 166
• Mol File: 1441-97-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 44-45℃
• Boiling Point: 257℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.10
• Vapor Pressure: 0.0152mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: o-(Methylthio)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: o-(Methylthio)acetophenone(1441-97-0)
• EPA Substance Registry System: o-(Methylthio)acetophenone(1441-97-0)

Safety Data

• Hazardous Substances Data: 1441-97-0(Hazardous Substances Data)

Usage

General Description

O-(Methylthio)acetophenone, also known as 2'-thioacetophenone, is a chemical compound with the molecular formula C9H10OS. It is a white crystalline solid that is used as a flavoring agent and fragrance ingredient in the food and cosmetic industries. O-(Methylthio)acetophenone has a strong, sweet, and sulfurous odor and is often used to add a garlic-like aroma to various products. It is also utilized in organic synthesis as a building block for the production of other chemicals and pharmaceuticals. Additionally, O-(Methylthio)acetophenone has shown potential antibacterial properties and could be used in the development of new antimicrobial agents. However, it is important to handle this compound with caution as it may cause irritation to the skin, eyes, and respiratory tract.

InChI:InChI=1/C9H10OS/c1-7(10)8-5-3-4-6-9(8)11-2/h3-6H,1-2H3

Upstream product

• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 917-54-4 methyllithium 
• 3724-10-5 2-(methylthio)benzoic acid 
• 79-20-9 acetic acid methyl ester 
• 19614-16-5 2-bromo-1-(methylsulfanyl)benzene 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 616-38-6 carbonic acid dimethyl ester 
• 5188-07-8 sodium thiomethoxide 
• 7022-44-8 2-Methylmercaptobenzoesaeure-methylanilid 
• 118-92-3 anthranilic acid 
• 65-85-0 benzoic acid 
• 2142-69-0 2-bromophenyl methyl ketone 
• 50777-64-5 2-(2-bromophenyl)-2-methyl-1,3-dioxolane 

Downstream Products

• 26524-93-6 2'-Methylsulfinyl-acetophenon 
• 118362-21-3 C₁₆H₁₇NO₃S₂ 
• 3323-76-0 1-(2-Methanesulfonyl-phenyl)-ethanone 
• 618388-75-3 2-(2-methylthiophenyl)hept-3-yn-2-ol 
• 1359978-83-8 (Z)-1-(2-(2-(methylthio)-2-(thiophen-2-yl)vinyl)phenyl)ethanone 
• 1359978-84-9 (Z)-1-(2-(2-(4-bromophenyl)-2-(methylthio)vinyl)phenyl)ethanone 
• 1359978-81-6 (Z)-1-(2-(2-(methylthio)oct-1-en-1-yl)phenyl)ethanone 
• 1359978-78-1 (Z)-1-(2-(2-(methylthio)-2-phenylvinyl)phenyl)ethanone 
• 1359978-77-0 (E)-N'-(1-(2-((Z)-2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 1359978-79-2 (Z)-1-(2-(2-(3,5-bis(trifluoromethyl)phenyl)-2-(methylthio)vinyl)phenyl)ethanone 
• 1359978-80-5 (Z)-1-(2-(2-(4-methoxyphenyl)-2-(methylthio)vinyl)phenyl)ethanone 
• 1362860-01-2 [Rh(bis(di-tert-butylphosphino)methane)(κ2-(S,O)-2-SMe-C6H4COMe)][B(C6H3-3,5-(CF3)2)4] 
• 171258-05-2 1-(2-(3,3-dimethylbut-1-yn-1-yl)phenyl)ethan-1-one 
• 171258-03-0 1-(2-(oct-1-ynyl)phenyl)ethanone 

Relevant articles and documents

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Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions

A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta

Methyl aryl thioether compound, and synthetic method and applications thereof

The invention discloses a methyl aryl thioether compound represented by formula 2, and a synthetic method and applications thereof. According to the synthetic method, in a reaction solvent, an aryl halide or an aromatic halide, dimethyl carbonate, and potassium thioacetate are taken as reaction raw materials, reaction is carried out in the presence of metal palladium catalyst under the action of a ligand and an alkali so as to obtain the methyl aryl thioether compound. The reaction conditions of the synthetic method are mild; the raw materials are cheap and easily available; reaction operation is simple; yield is relatively high. The methyl aryl thioether compound can be used for providing skeleton structures for the synthesis of a plurality of natural products and medicines, and can be widely applied in industrialized large-scale production.

Iodine-catalyzed intramolecular oxidative thiolation of vinylic carbon-hydrogen bonds via tandem iodocyclization and dehydroiodination: Construction of 2-methylene-3-thiophenones

A metal-free vinylic carbon-hydrogen bond thiolation has been developed. Under the catalysis of iodine (10 mol%), the cyclization of α-alkenoyl ketene dithioacetals afforded a broad range of polyfunctionalized 2-methylene-3-thiophenones in good selectivity with moderate to excellent yields via tandem iodocyclization and dehydroiodination. The synthetic strategy can also be extended to the cyclization of ortho-methylthiophenyl vinyl ketones leading to 2-methylene-3-benzothiophenones.